Tunisian officials say Mr Ghanem - a former prime minister - crossed into Tunisia by road before going to the island of Djerba.
A spokesman for the Libyan rebels told the BBC the minister had defected, and was on his way to a European country.
The Libyan government said he had been on official business in Tunisia, but that Tripoli had lost touch with him.
The BBC's Andrew North, in Tripoli, says that if Mr Ghanem's defection is confirmed, he would be the highest-level figure to go since Libya's former Foreign Minister Moussa Koussa fled to the UK in March.
"Shukri Ghanem has left Libya," a Tunisian official told AFP news agency. The official added that Mr Ghanem had gone to a hotel in Djerba but "not tried to contact the Tunisian authorities".
A UK-based spokesman for the rebel Transitional National Council, Jumaa el Gamaty, told the BBC: "Mr Shukri Ghanem has defected. I think as we speak he's in [a] transitory European country."
Libyan government spokesman Moussa Ibrahim said Tripoli had lost contact with him.
Mr Ibrahim told the New York Times newspaper that the government's fight against rebels "doesn't depend on individuals, even if they are high-ranking officials".
A spokesman for the Libyan rebels told the BBC the minister had defected, and was on his way to a European country.
The Libyan government said he had been on official business in Tunisia, but that Tripoli had lost touch with him.
The BBC's Andrew North, in Tripoli, says that if Mr Ghanem's defection is confirmed, he would be the highest-level figure to go since Libya's former Foreign Minister Moussa Koussa fled to the UK in March.
"Shukri Ghanem has left Libya," a Tunisian official told AFP news agency. The official added that Mr Ghanem had gone to a hotel in Djerba but "not tried to contact the Tunisian authorities".
A UK-based spokesman for the rebel Transitional National Council, Jumaa el Gamaty, told the BBC: "Mr Shukri Ghanem has defected. I think as we speak he's in [a] transitory European country."
Libyan government spokesman Moussa Ibrahim said Tripoli had lost contact with him.
Mr Ibrahim told the New York Times newspaper that the government's fight against rebels "doesn't depend on individuals, even if they are high-ranking officials".

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